The Effect of Moderate-intensity Continuous Exercise and Nanocurcumine Supplementation on STAT3 Gene Expression in Rats With Glioblastoma Multiforme Brain Tumor

Background and Objectives Continuous exercise with moderate intensity the use of nanocurcumin supplementation has potential to control reduce tumors central nervous system, including glioblastoma. We assessed simultaneous effect moderate-intensity continuous exercises on STAT3 gene expression in mice glioblastoma multiforme brain tumors. Subjects Methods Thirty-five male Wistar rats were randomly divided into seven groups five rats: basal (BC), 4-week (4wC), cancer (BT), (4 wT), cancer+training (TE), cancer+nanocurcumin (TN), cancer+ + (TEN). After injection cells forehead, animals treated by gavage at dose 80 mg/kg for 28 days, days a week, started training treadmill four weeks, three days/weeks, 25 40 minutes per week speed 18 m/min. Finally, then sacrificed data collected. Results Moderate-intensity significantly reduced tumor volume TEN group (P<0.05). But this decrease was not significant TE TN groups. Conclusion It seems that decreased size, combination therapeutic role treatment process